TY - JOUR AU - Ornstein, Moshe C. AU - Garcia, Jorge A. AU - Sharifi, Nima PY - 2016 TI - Screening for functional kinases in metastatic prostate cancer: a glimmer of hope for kinase inhibition JF - Translational Andrology and Urology; Vol 5, No 4 (August 01, 2016): Translational Andrology and Urology (Ejaculatory Dysfunction) Y2 - 2016 KW - N2 - Understanding the molecular biology of castration-resistant prostate cancer (CRPC) has led to a dramatic paradigm shift in the treatment of patients with metastatic disease where the androgen receptor (AR) is a central therapeutic target in the disease. Despite these major advances, disease biology and the well-recognized heterogeneity of prostate cancer (PCa) are some of the inherent disease-specific issues that continue to affect clinical trial design, drug development and ultimately patient outcomes. UR - https://tau.amegroups.org/article/view/10590