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Comprehensive bioinformatics and experimental analysis of PPOX reveals its carcinogenic effect in clear cell renal cell carcinoma

   
@article{TAU154406,
	author = {Kaibin Wang and Lili Wang and Yuanhao Zhang and Dingkun Hou and Lijuan Kang and Zheng Qin and Xiao Zhu and Changying Li and Haitao Wang},
	title = {Comprehensive bioinformatics and experimental analysis of PPOX reveals its carcinogenic effect in clear cell renal cell carcinoma},
	journal = {Translational Andrology and Urology},
	volume = {15},
	number = {5},
	year = {2026},
	keywords = {},
	abstract = {Dysregulated heme biosynthesis is a hallmark of metabolic reprogramming in cancer; however, the role of protoporphyrinogen oxidase (PPOX), the penultimate enzyme in the heme synthesis pathway, remains poorly characterized in clear cell renal cell carcinoma (ccRCC). This study aims to elucidate the regulatory mechanism of PPOX on the malignant phenotype of ccRCC to evaluate its potential as a precision biomarker.},
	issn = {2223-4691},	url = {https://tau.amegroups.org/article/view/154406}
}