TY  - JOUR
AU  - Ha, Tanya
AU  - Xu, Jie Hua
PY  - 2017
TI  - Interstitial cystitis intravesical therapy
JF  - Translational Andrology and Urology; Vol 6, Supplement 2 (July 19, 2017): Translational Andrology and Urology (Functional Urology)
Y2  - 2017
KW  - 
N2  - Interstitial cystitis (IC) is a progressive bladder disorder that presents with symptoms of bladder urgency, frequency and pain. The aetiology of the disease remains uncertain, but it is postulated that there is an initial infective insult which damages the glycosaminoglycan (GAG) layer of the bladder urothelium. This defect allows an influx of ions, particularly potassium, which initiates an inflammatory reaction in the bladder wall, which incites the symptoms described above. Treatment initially involves behavioural and oral medication, with second line being intravesical instillation therapy. Treatment strategies focus on restoring lower urinary tract epithelial function, inhibiting neural activation, controlling allergies and relieving symptoms. In this review, current intravesical therapy will be discussed, as well as what lies on the horizon for intravesical therapy in IC.
UR  - https://tau.amegroups.org/article/view/15623