@article{TAU157216,
author = {Gülsüm Helvacı and Aylin Bilgin and Arthur L. Burnett and Sena F. Sezen},
title = {Stem cell therapy for erectile dysfunction: a systematic review and meta-analysis},
journal = {Translational Andrology and Urology},
volume = {15},
number = {7},
year = {2026},
keywords = {},
abstract = {Background: Erectile dysfunction (ED) is a prevalent sexual dysfunction, and due to the limited efficacy of conventional treatments, stem cell (SC)-based regenerative approaches are being extensively investigated. We aimed to investigate the overall effect of SC therapy (SCT) on ED by consolidating findings from clinical studies and offering a general overview of the intervention content and design of these studies.Methods: A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We systematically reviewed MEDLINE, PubMed, Web of Science and ClinicalTrials.gov from inception to July 26, 2024. The outcomes were analyzed using the Comprehensive Meta-Analysis software version 3.0. The Q statistic and I2 statistics were used to evaluate heterogeneity.Results: In this meta-analysis, a total of 11 studies evaluated International Index of Erectile Function (IIEF) levels, with an overall mean effect estimated at 16.872 [95% confidence interval (CI): 13.311–20.432]. The findings demonstrated statistically significant improvements in IIEF (Z=9.288, P},
issn = {2223-4691}, url = {https://tau.amegroups.org/article/view/157216}
}