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Should we spare neoadjuvant chemotherapy in low-risk muscle-invasive bladder cancer patients scheduled for radical cystectomy?

   
@article{TAU25375,
	author = {Günter Niegisch},
	title = {Should we spare neoadjuvant chemotherapy in low-risk muscle-invasive bladder cancer patients scheduled for radical cystectomy?},
	journal = {Translational Andrology and Urology},
	volume = {8},
	number = {Suppl 3},
	year = {2019},
	keywords = {},
	abstract = {There is an ongoing debate whether every eligible patient suffering from muscle-invasive bladder cancer should undergo cisplatin-based neoadjuvant chemotherapy (NAC) before definitive treatment by radical cystectomy. Supporters of this approach refer to level 1 evidence given by high quality meta-analyses indicating a survival benefit of at least 5% improvement in 5-year overall survival by NAC (Table 1) (1-5). Given that most patients relapsing from bladder cancer will present with distant metastases rather than local recurrence (6,7), NAC is thought to tackle micrometastatic disease.},
	issn = {2223-4691},	url = {https://tau.amegroups.org/article/view/25375}
}