@article{TAU33064,
author = {Joon Yau Leong and Ruben Blachman-Braun and Amir Shahreza Patel and Premal Patel and Ranjith Ramasamy},
title = {Association between polychlorinated biphenyl 153 exposure and serum testosterone levels: analysis of the National Health and Nutrition Examination Survey},
journal = {Translational Andrology and Urology},
volume = {8},
number = {6},
year = {2019},
keywords = {},
abstract = {Background: To examine the effects of environmental polychlorinated biphenyls (PCBs) 153 exposure, an industrial plasticizer, on serum testosterone levels.
Methods: Using data collected from the 1999–2000 and 2001–2002 National Health and Nutrition Examination Survey (NHANES), we analyzed serum total testosterone and PCB153 levels, demographic data and comorbidities for men aged 18 years and older. Univariate and multivariate linear regression analysis was used to evaluate the association between total testosterone and serum PCB153.
Results: Five hundred and fifty-seven men met inclusion criteria. Median age was 45.7 [33.4–60.4] years old while median serum total testosterone and PCB153 levels were 479 [352.5–607] ng/dL and 0.20 [0.11– 0.39] ng/g, respectively. Increasing age, higher body mass index (BMI), higher levels of serum PCB153, lower levels of activity and a history of diabetes mellitus and coronary heart disease were associated with decreasing serum testosterone levels on univariate linear regression. On multivariate linear regression, increasing age (estimate −6.29 ng/dL per year of life, P},
issn = {2223-4691}, url = {https://tau.amegroups.org/article/view/33064}
}