@article{TAU692,
author = {Chung Lee and Qiang Zhang and Xaolin Zi and Atreya Dash and Marcelo B Soares and Farahnaz Rahmatpanah and Zhenyu Jia and Michael McClelland and Dan Mercola},
title = {TGF-β mediated DNA methylation in prostate cancer},
journal = {Translational Andrology and Urology},
volume = {1},
number = {2},
year = {2012},
keywords = {},
abstract = {Almost all tumors harbor a defective negative feedback loop of signaling by transforming growth factor-β (TGF-β). Epigenetic mechanisms of gene regulation, including DNA methylation, are fundamental to normal cellular function and also play a major role in carcinogenesis. Recent evidence demonstrated that TGF-β signaling mediates cancer development and progression. Many key events in TGF-β signaling in cancer included auto-induction of TGF-β1 and increased expression of DNA methyltransferases (DNMTs), suggesting that DNA methylation plays a significant role in cancer development and progression. In this review, we performed an extensive survey of the literature linking TGF-β signaling to DNA methylation in prostate cancer. It appeared that almost all DNA methylated genes detected in prostate cancer are directly or indirectly related to TGF-β signaling. This knowledge has provided a basis for our future directions of prostate cancer research and strategies for prevention and therapy for prostate cancer.},
issn = {2223-4691}, url = {https://tau.amegroups.org/article/view/692}
}