@article{TAU8088,
author = {Robert E. Hurst and Beverley Greenwood-Van Meerveld and Amy B. Wisniewski and Samuel VanGordon and Hsueh Kung Lin and Bradley P. Kropp and Rheal A. Towner},
title = {Increased bladder permeability in interstitial cystitis/painful bladder syndrome},
journal = {Translational Andrology and Urology},
volume = {4},
number = {5},
year = {2015},
keywords = {},
abstract = {The definition of interstitial cystitis (IC) has evolved over the years from being a well-defined entity characterized by diagnostic lesion (Hunner’s ulcer) in the urothelium to a clinical diagnosis by exclusion [painful bladder syndrome (PBS)]. Although the etiology is unknown, a central theme has been an association with increased permeability of the bladder. This article reviews the evidence for increased permeability being important to the symptoms of interstitial cystitis/painful bladder syndrome (IC/PBS) and in treating the disorder. Recent work showing cross-communication among visceral organs is also reviewed to provide a basis for understanding IC/PBS as a systemic disorder of a complex, interconnected system consisting of the bladder, bowel and other organs, nerves, cytokine-responding cells and the nervous system.},
issn = {2223-4691}, url = {https://tau.amegroups.org/article/view/8088}
}