Printed Abstracts
AB204. Repeated intradetrusor botulinum toxin type A injections are still effective for patients with neurogenic detrusor overactivity secondary to spinal cord injury in China
Hui Chen1,2, Xinghua Yang3, Jingwen Zeng2, Maping Huang3, Qiuling Liu3, Jiebing Huang3, Tianhai Huang4, Keji Xie4, Chonghe Jiang2
1Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital and Jinan University, Guangzhou 510900, China; 2Departments of Urology, Qingyan City People’s Hospital, Jinan University, Qingyan, China; 3Department of Spinal Cord Injury Recovery Center, Guangdong Provincial Work Injury Rehabilitation Hospital, Guangzhou 510900, China; 4Department of Urology, Guangzhou First Municipal People’s Hospital, Guangzhou 510180, China
Objective: To assess effective outcomes following repeated treatment with intradetrusor botulinum toxin type A in patients with neurogenic detrusor overactivity (NDO).
Methods: Patients with NDO secondary to spinal cord injury (SCI) were enrolled. Botulinum toxin type A 200 U detrusor injections by a rigid cystoscope were repeated. Primary outcomes were urodynamic variables including maximum detrusor pressure during first involuntary detrusor contraction (Pdetmax IDC) filling cystometry, detrusor compliance (DC). Secondary outcomes were improvement of the patient’s quality of life (QoL) measured by Incontinence-Specific Quality-of-Life Instrument (I-QoL), the validated short forms of Urogenital Distress Inventory (UDI-6) and the Incontinence Impact Questionnaire (IIQ-7). Related adverse events were recorded.
Results: From 2012 to 2014, 159 injections were performed in 52 patients (44 male, 8 female). The mean age was 36.67 years. The maximum number of repeated injections was five. BC increased from (4.03–7.45) to (6.96–10.86) mL/cmH2O, Pdetmax in bladder storage decreased from (42.80–79.52) to (26.40–43.33) cmH2O, respectively. The I-QoL, UDI-6 and IIQ-7 showed a consistent improvement after repeated injections.
Conclusions: Repeated intradetrusor botulinum toxin type A injections remain improve QoL in patients with NDO secondary to SCI.
Keywords: Botulinum toxin type A; detrusor overactivity; neurogenic; spinal cord injury (SCI); quality of life (QoL)
doi: 10.21037/tau.2016.s204
Cite this abstract as: Chen H, Yang X, Zeng J, Huang M, Liu Q, Huang J, Huang T, Xie K, Jiang C. Repeated intradetrusor botulinum toxin type A injections are still effective for patients with neurogenic detrusor overactivity secondary to spinal cord injury in China. Transl Androl Urol 2016;5(Suppl 1):AB204. doi: 10.21037/tau.2016.s204
