A comparative study of survival outcomes between partial and radical cystectomy in octogenarians with muscle-invasive bladder cancer
Highlight box
Key findings
• Partial cystectomy (PC) is not inferior to radical cystectomy (RC) among octogenarians with muscle-invasive urothelial bladder carcinoma.
What is known and what is new?
• RC is the preferred standard of care for the muscle-invasive bladder cancer.
• In this National Cancer Database-related study, we observed that PC may not be inferior to RC in terms of overall survival among carefully selected octogenarians with well-defined criteria. Therefore, role of PC needs further evaluation.
What is the implication and what should change now?
• This finding could help in patient counselling and shared-decision making among octogenarians with carcinoma bladder. Concern about the oncological outcomes and the need for salvage cystectomy limits the utilization of PC. With the evolution of bladder preservation protocols, further exploration on the PC by incorporating with other strategies like chemoradiation may help us understand its role in bladder preservation.
Introduction
Bladder carcinoma is the 10th most common cancer worldwide, and in the United States, it is ranked as the 6th most common cancer. American Cancer Society estimated that in 2023, approximately 82,290 new cases and 16,710 mortality to occur due to bladder carcinoma (1). The life expectancy of an individual has been increasing over the years, and the average overall life expectancy is 76 years. In males and females, the average life expectancy is 73 and 79.3 years, respectively (2). The life expectancy for an 80-year-old individual ranges between 8 and 10 years, which may vary based on associated co-morbidities, and in the United States, life expectancy for men and women aged 80 years is 7 and 9.1 years, respectively (3,4). As the age increases, the incidence of carcinoma bladder increases, with a median age of 73 years during diagnosis (5). In the United States, carcinoma bladder cancer ranked as the 4th most common cause of death among individuals aged 80 and above. During diagnosis, around 20% to 30% are found to have muscle-invasive bladder cancer (MIBC) (6). With the advancements in the healthcare system and the increase in life expectancy, many individuals in their eighties are undergoing major surgeries.
The preferred first-line treatment for MIBC is neoadjuvant chemotherapy with radical cystectomy (RC), and its effectiveness has been well documented. However, some elderly individuals, due to their concern about the morbidity associated with RC and the limited overall survival (OS) for age, consider bladder preservation options like partial cystectomy (PC) and concurrent chemoradiation. PC was used in earlier days to treat bladder cancer, but due to the lack of definitive indications and concerns about treatment failure and disease progression, the use has been limited. Current National Comprehensive Cancer Network guidelines suggest PC can be considered a viable option in carefully selected individuals with MIBC (7). The objective of the study is to evaluate the survival outcomes in octogenarians treated with RC and PC using the National Cancer Database (NCDB). We present this article in accordance with the STROBE reporting checklist (available at https://tau.amegroups.com/article/view/10.21037/tau-24-139/rc).
Methods
Patient selection
In our retrospective study using NCDB, we identified individuals aged 80 years and above with localized MIBC (cT2–4aN0M0) with less than 5cm tumor size and urothelial histology diagnosed between 2004 and 2018. The NCDB is a comprehensive nationwide database that covers approximately 70% of all oncological cases in the United States. The data utilized in the study is deidentified data provided as a participant user file. All collected information adheres to Health Insurance Portability and Accountability Act regulations. NCDB data undergo regular validation through yearly quality monitoring checks (8,9). As the data entered are publicly available on request, which are deidentified and not re-identifiable, and as human subjects are not directly involved in the study purpose, institutional review board approval was not necessary. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). Depending on the treatment modalities, patients who met our selection criteria were divided into PC and RC groups. PC group included those who underwent PC (coded as PC) with or without chemotherapy/radiotherapy. RC group included those who underwent RC (coded as RC/total cystectomy) with or without chemotherapy/radiotherapy. We excluded patients who received other treatments, non-urothelial histology, and missing data (clinical T, clinical N, histology, treatment, follow-up, and vital status). Based on the inclusion and exclusion criteria, we identified 2,528 octogenarians who were included in our final analysis (Figure 1).
![Click on image to zoom](http://cdn.amegroups.cn/journals/amepc/files/journals/3/articles/127698/public/127698-PB6-4112-R1.jpg/w300)
Statistical analyses
We compared the treatment groups using sociodemographic parameters such as gender, race and ethnicity, insurance, treatment facility, median income, and clinical parameters such as comorbidity index, tumor size, clinical stage, and tumor grading. Race and ethnicity were categorized into white, black, Asian, other/unknown, and Hispanic or non-Hispanic, as only a small proportion of patients were present in some classes. The sociodemographic and clinical parameters were analyzed using the chi-squared test and contingency tables. Later, a 1:1 propensity matching between the 2 treatment arms among the octogenarian population was conducted to limit the potential bias and the effects of possible confounding factors. Facility type, gender, ethnicity, race, median income, comorbidity index, clinical T, tumor grade, and tumor size were the parameters used for propensity matching. After matching, we identified 285 patients who underwent PC and 285 who underwent RC. We used Kaplan-Meier survival analysis and multivariate Cox regression analyses to compare the OS between both treatment modalities, and a P value <0.05 was considered statistically significant. SAS statistical software, version 9.4, was used to perform the analyses.
Results
There were 671,462 patients diagnosed with bladder carcinoma between 2004 and 2018. Among these patients, 94,103 patients had localized MIBC. Of these patients, 2,528 patients aged 80 or above met our selection criteria being treated with PC or RC following the exclusion of patients with incomplete survival or follow-up data (Figure 1). In this octogenarian cohort, 313 patients underwent PC, and 2,215 underwent RC. After 1:1 propensity-matching, PC and RC groups had 285 and 281 patients, respectively (Figure 1). The mean follow-up of PC and RC patients were 39.5 and 36.3 months, respectively. In the univariate analysis (Table 1), the average and median age in the PC group were 84.1±3.3 and 83 years, and in the RC group were 82.9±2.5 and 82 years, respectively. 138 (44.1%) of patients who underwent PC were treated in community centers, and 88 (28.1%) were treated in academic centers (P<0.001). Similarly, 1,073 (48.4%) of patients who underwent RC were treated in academic centers, and 668 (30.2%) were treated in community centers (P<0.001). In both the PC and RC cohorts, most of the patients had T2 tumors (79.2% vs. 83.9%) (P<0.001). Among the patients who underwent PC, most of the tumors were located in the dome, lateral, anterior, and posterior walls. Among patients who underwent PC, 57 (18.2%) patients had margin positivity, whereas 270 (12.2%) in the RC arm had margin positivity (P<0.001). Pelvic lymph node dissection was done in 151 (48.2%) PC patients, while 1,967 (88.8%) RC patients had lymph node dissection (P<0.001). Lymph node positivity was noted in 17 (5.4%) of PC patients and 474 (21.4%) of RC patients (P<0.001). The utilization of neoadjuvant chemotherapy was limited in both PC and RC groups, with 50 (16.0%) and 357 (16.1%), respectively (P=0.003). The 30-day mortality in PC and RC group were 8 (2.6%) and 108 (4.9%), respectively (P=0.001) and the 90-day mortality was 16 (5.1%) and 226 (10.2%), respectively (P=0.01). Mean hospital stay for PC and RC arms were 5.4 (8.5) days and 10.2 (9.7) days, respectively (P<0.001). Among patients who underwent PC and RC, radiation was used limitedly in both groups, 23 (7.3%) and 31 (1.4%), respectively. Similarly, adjuvant chemotherapy was also used limitedly, 20 (6.4%) and 102 (4.6%), respectively. However, there were no statistically significant differences in gender, race, ethnicity, median income, education, insurance, comorbidity index, tumor grade, and 30-day readmission.
Table 1
Parameters | Unmatched population | Matched population | |||||
---|---|---|---|---|---|---|---|
PC (N=313) | RC (N=2,215) | P value | PC (N=285) | RC (N=281) | P value | ||
Age (years) | <0.001 | <0.001 | |||||
Mean ± SD | 84.1±3.3 | 82.9±2.5 | 84.1±3.3 | 83±2.6 | |||
Median | 83 | 82 | 83.5 | 83 | |||
Gender | 0.97 | 0.84 | |||||
Male | 224 (71.6) | 1,587 (71.6) | 202 (70.9) | 197 (70.1) | |||
Female | 89 (28.4) | 628 (28.4) | 83 (29.1) | 84 (29.9) | |||
Race | 0.47 | 0.46 | |||||
White | 289 (92.3) | 2,082 (94.0) | 262 (91.9) | 264 (94.0) | |||
Black | 12 (3.8) | 78 (3.5) | 11 (3.9) | 10 (3.6) | |||
Asian | 8 (2.6) | 28 (1.3) | 8 (2.8) | 4 (1.4) | |||
Others | 4 (1.2) | 27 (1.2) | 4 (1.4) | 3 (1.1) | |||
Ethnicity | 0.79 | 0.52 | |||||
Non-Hispanic | 296 (94.6) | 2,098 (94.7) | 268 (94.0) | 269 (95.7) | |||
Hispanic | 5 (1.6) | 44 (2.0) | 5 (1.8) | 5 (1.8) | |||
Unknown | 12 (3.8) | 73 (3.3) | 12 (4.2) | 7 (2.5) | |||
Median income | 0.74 | 0.89 | |||||
<$40,227 | 37 (13.0) | 274 (13.8) | 37 (13.0) | 41 (14.6) | |||
$40,227–50,353 | 71 (24.9) | 451 (22.7) | 71 (24.9) | 64 (22.8) | |||
$50,354–63,332 | 70 (24.6) | 535 (26.9) | 70 (24.6) | 67 (23.8) | |||
≥$63,333 | 107 (37.5) | 730 (36.7) | 107 (37.5) | 109 (38.8) | |||
Unknown | 28 | 225 | |||||
Insurance | 0.50 | 0.71 | |||||
Not insured | 0 (0.0) | 9 (0.4) | 0 | 2 (0.7) | |||
Private | 26 (8.3) | 166 (7.5) | 23 (8.1) | 22 (7.8) | |||
Medicaid | 1 (0.3) | 28 (1.3) | 1 (0.4) | 2 (0.7) | |||
Medicare | 282 (90.1) | 1,982 (89.5) | 257 (90.2) | 251 (89.3) | |||
Others | 4 (1.3) | 30 (1.3) | 4 (1.4) | 4 (1.4) | |||
Facility type | <0.001 | 0.85 | |||||
Community CP | 23 (7.3) | 100 (4.5) | 22 (7.7) | 23 (8.2) | |||
Comprehensive CCP | 138 (44.1) | 668 (30.2) | 125 (43.9) | 119 (42.3) | |||
Academic program | 88 (28.1) | 1,073 (48.4) | 79 (27.7) | 86 (30.6) | |||
Integrated network CP | 64 (20.4) | 374 (16.9) | 59 (20.7) | 53 (18.9) | |||
Comorbidity index | 0.08 | 0.76 | |||||
0 | 200 (63.9) | 1,430 (64.6) | 181 (63.5) | 184 (65.5) | |||
1 | 70 (22.4) | 556 (25.1) | 64 (22.5) | 64 (22.8) | |||
2 | 27 (8.6) | 170 (7.7) | 26 (9.1) | 24 (8.5) | |||
3 | 16 (5.1) | 59 (2.7) | 14 (4.9) | 9 (3.2) | |||
Clinical T | <0.001 | 0.47 | |||||
cT2 | 248 (79.2) | 1,858 (83.9) | 221 (77.5) | 226 (80.4) | |||
cT3 | 60 (19.2) | 261 (11.8) | 59 (20.7) | 48 (17.1) | |||
cT4 | 5 (1.6) | 96 (4.3) | 5 (1.8) | 7 (2.5) | |||
Pathological T | <0.001 | <0.001 | |||||
≤ pT1 | 12 (3.8) | 362 (16.3) | 11 (3.9) | 35 (12.5) | |||
pT2 | 97 (31.0) | 600 (27.1) | 84 (29.5) | 68 (24.2) | |||
pT3 | 126 (40.3) | 943 (42.6) | 117 (41.1) | 135 (48.0) | |||
pT4 | 2 (0.6) | 37 (1.7) | 2 (0.7) | 1 (0.4) | |||
pTx | 65 (20.8) | 231 (10.4) | 62 (21.8) | 33 (11.7) | |||
Unknown | 11 (3.5) | 42 (1.9) | 9 (3.2) | 9 (3.2) | |||
Pathological N | <0.001 | <0.001 | |||||
pN0 | 153 (48.9) | 1,433 (64.7) | 137 (48.1) | 177 (63.0) | |||
pN+ | 16 (5.1) | 431 (19.5) | 16 (5.6) | 53 (18.9) | |||
pNx | 122 (39.0) | 296 (13.4) | 114 (40.0) | 42 (14.9) | |||
Unknown | 22 (7.0) | 55 (2.5) | 18 (6.3) | 9 (3.2) | |||
Tumor location | <0.001 | <0.001 | |||||
Dome | 109 (34.8) | 87 (3.9) | 102 (35.8) | 11 (3.9) | |||
Lateral wall | 48 (15.3) | 372 (16.8) | 44 (15.4) | 41 (14.6) | |||
Anterior wall | 30 (9.6) | 82 (3.7) | 25 (8.8) | 9 (3.2) | |||
Posterior wall | 23 (7.3) | 192 (8.7) | 21 (7.4) | 21 (7.5) | |||
Others | 36 (11.5) | 707 (31.9) | 30 (10.5) | 92 (32.7) | |||
Bladder, NOS | 67 (21.4) | 775 (35.0) | 63 (22.1) | 107 (38.1) | |||
Surgical margin | <0.001 | <0.001 | |||||
Negative | 234 (74.8) | 1,864 (84.2) | 211 (74.0) | 244 (86.8) | |||
Positive | 57 (18.2) | 270 (12.2) | 54 (18.9) | 25 (8.9) | |||
Unknown | 22 (7.0) | 81 (3.7) | 20 (7.0) | 12 (4.3) | |||
Tumor grade | 0.38 | 0.36 | |||||
Grade I | 1 (0.3) | 9 (0.4) | 0 (0.0) | 1 (0.4) | |||
Grade II | 6 (1.9) | 57 (2.6) | 2 (0.7) | 7 (2.5) | |||
Grade III | 129 (41.2) | 793 (35.8) | 122 (42.8) | 111 (39.5) | |||
Grade IV | 153 (48.9) | 1,145 (51.7) | 138 (48.4) | 138 (49.1) | |||
Unknown | 24 (7.7) | 211 (9.5) | 23 (8.1) | 24 (8.5) | |||
LN dissection | <0.001 | <0.001 | |||||
No | 162 (51.8) | 248 (11.2) | 149 (52.3) | 28 (10.0) | |||
Yes | 151 (48.2) | 1,967 (88.8) | 136 (47.7) | 253 (90.0) | |||
30-day mortality | 0.001 | 0.03 | |||||
Alive | 305 (97.4) | 2,107 (95.1) | 277 (97.2) | 262 (93.2) | |||
Dead | 8 (2.6) | 108 (4.9) | 8 (2.8) | 19 (6.8) | |||
90-day mortality | 0.01 | 0.01 | |||||
Alive | 297 (94.9) | 1,989 (89.8) | 269 (94.4) | 248 (88.3) | |||
Dead | 16 (5.1) | 226 (10.2) | 16 (5.6) | 33 (11.7) | |||
Neoadjuvant | 0.003 | 0.27 | |||||
No | 225 (71.9) | 1,707 (77.1) | 207 (72.6) | 216 (76.9) | |||
Yes | 50 (16.0) | 357 (16.1) | 42 (14.7) | 41 (14.6) | |||
Unknown | 38 (12.1) | 151 (6.8) | 36 (12.6) | 24 (8.5) | |||
Radiation | <0.001 | <0.001 | |||||
Yes | 23 (7.3) | 31 (1.4) | 21 (7.4) | 4 (1.4) | |||
No | 290 (92.7) | 2,184 (98.6) | 264 (92.6) | 277 (98.6) |
Data are presented as n (%) unless otherwise specified. PC, partial cystectomy; RC, radical cystectomy; CCP, comprehensive cancer program, CP, cancer program; cT, clinical T; pT, pathological T; pN, pathological N; LN, lymph node; NOS, not otherwise specified; SD, standard deviation.
Kaplan-Meier survival analysis for the unmatched population of PC and RC (Figure 2A) showed that the median OS was 34.3 (95% CI, 28.4–41.5) and 30.2 (95% CI, 27.5–33.9) months, respectively (P=0.72), and for the matched population (Figure 2B) was 33.4 (95% CI, 26.6–39.3) and 29.9 (95% CI, 25.3–39.6) months, respectively (P=0.68). In T2 tumors the median OS for the unmatched population of PC and RC (Figure 3A) was 38.3 (95% CI, 31.6–46.7) and 33.3 (95% CI, 30.3–37.7) months (P=0.82), and for the matched population (Figure 3B) was 37 (95% CI, 29.8–45.8) and 33.5 (95% CI, 25.6–43.8) months, respectively (P=0.52). Likewise, in T3 tumors the median OS for the unmatched population of PC and RC (Figure 3C) was 22.3 (95% CI, 14.1–34.2) and 20.1 (95% CI, 15.3–28.9) months, respectively (P=0.70), and for the matched population (Figure 3D) was 22.3 (95% CI, 14.1–34.2) and 24.4 (95% CI, 13.7–41.3) months, respectively (P=0.98). Multivariate Cox regression analysis (Table 2) showed there was no difference in the risk of mortality between PC and RC (HR =1.15; 95% CI, 0.99–1.34; P=0.07). Similarly, there was no significant difference in survival hazards between tumor locations.
![Click on image to zoom](http://cdn.amegroups.cn/journals/amepc/files/journals/3/articles/127698/public/127698-PB7-5877-R1.jpg/w300)
![Click on image to zoom](http://cdn.amegroups.cn/journals/amepc/files/journals/3/articles/127698/public/127698-PB8-2764-R1.jpg/w300)
Table 2
Parameter | Hazard ratio | 95% confidence interval | P value |
---|---|---|---|
Intervention | |||
Partial cystectomy | Ref. | ||
Radical cystectomy | 1.15 | 0.99–1.34 | 0.07 |
Facility type | |||
Community CP | Ref. | ||
Comprehensive CCP | 0.98 | 0.78–1.23 | 0.04 |
Academic center | 0.90 | 0.72–1.13 | 0.80 |
Integrated network | 0.96 | 0.75–1.23 | 0.10 |
Comorbidity score | |||
0 | Ref. | ||
1 | 1.15 | 1.03–1.29 | 0.01 |
2 | 1.41 | 1.18–1.67 | 0.0001 |
≥3 | 1.30 | 0.97–1.73 | 0.08 |
Pathological T | |||
≤ pT1 | Ref. | ||
pT2 | 0.70 | 0.59–0.82 | <0.001 |
pT3 | 1.06 | 0.91–1.23 | 0.47 |
pT4 | 1.82 | 1.27–2.62 | 0.001 |
Pathological N | |||
pN+ | Ref. | ||
pN0 | 0.59 | 0.52–0.66 | <0.001 |
pNx | 0.66 | 0.51–0.85 | 0.001 |
LN dissection | |||
No | Ref. | ||
Yes | 0.88 | 0.75–1.04 | 0.13 |
Neoadjuvant | |||
No | Ref. | ||
Yes | 0.79 | 0.69–0.91 | 0.001 |
Tumor location | |||
Dome | Ref. | ||
Lateral wall | 0.95 | 0.77–1.18 | 0.66 |
Anterior wall | 1.02 | 0.77–1.35 | 0.90 |
Posterior wall | 0.89 | 0.70–1.14 | 0.36 |
Others | 1.02 | 0.83–1.25 | 0.85 |
Bladder, NOS | 0.92 | 0.75–1.12 | 0.39 |
CP, cancer program; CCP, community cancer program; pT, pathological T; LN, lymph node; NOS, not otherwise specified.
Discussion
Our study compared the survival outcomes between PC and RC in octogenarians with localized MIBC and observed that PC was safe and not inferior to RC. Patients treated in comprehensive Community cancer programs are more likely to undergo PC, and in academic centers, they are likely to undergo RC. The neoadjuvant chemotherapy was underutilized in both PC and RC patients, and pelvic lymph node dissection was less performed in PC compared to RC. The 30- and 90-day mortality rates were lower in PC. Tumors located in the dome of the bladder were mostly treated with PC, but on multivariate analysis, tumor location did not show a significant difference in survival hazards, and patients with higher comorbidity scores and those with T4 disease had increased mortality risk.
Over decades, the oncological and survival outcomes after PC have been a concern, so it was not performed as much. Few studies evaluated PC and compared the outcomes to the standard of care. Knoedler et al., in their study on localized MIBC treated with PC for urothelial carcinoma, observed no significant differences between PC and RC in terms of 10-year cancer-specific survival (CSS) (58% vs. 63%, P=0.63). However, retreatment for PC with RC was seen in 16 (18.6%) patients due to intravesical tumor recurrence (10). Studies have shown that in PC, 5-year recurrence-free (RFS) and OS were between 39–62% and 57–70%, respectively, and superficial tumors, clinical stage, and adjuvant chemotherapy were associated with RFS (11-13). In carefully selected individuals with solitary MIBC lesions, PC offered good control, and the factors associated with undergoing PC were age above 70 years (14,15). In a study by Chung et al. from the NCDB, RC had better OS than PC, but in T2 tumors <5 cm, the OS was comparable (16). In our study on octogenarians, we observed PC was not inferior in terms of OS compared to RC. Even though positive surgical margin status was higher in PC compared to RC, details on recurrence-free survival (RFS) and retreatment rates were unavailable.
Long et al., in their study from the SEER database, observed that 18.9% and 81.1% of patients underwent PC and RC, respectively. Even though the clinical and sociodemographic parameters were not similar in both treatment groups, they had similar oncologic outcomes after propensity matching. Among the patients who underwent PC and RC, 45.4% and 92.0% of patients had pelvic lymph node dissection (PLND), respectively. PLND performed for curative purposes may be necessary for better long-term survival (17). Mistretta et al. also observed that PLND was performed limitedly in patients treated with PC (18). Our study showed similar results, with 12.4% and 87.6% undergoing PC and RC, respectively. Also, 48.2% of PC and 88.8% of RC patients had PLND. There was a higher pN+ rate in the RC group than in the PC group, and PLND was performed less in PC compared to RC. This could have been due to the differences in patient selection based on the surgeon’s concern about the risk-benefit ratio from PLND in this advanced age group.
Studies have shown that utilization of NAC has been limited among patients who underwent PC, and the 30-day mortality rate in PC and RC was 1.6% and 2.1%, respectively (19). Peak et al. observed in their review that 7% to 10% of cystectomies performed for carcinoma bladder were PC; only 2.8% were MIBC (20). Our research on octogenarians also observed limited use of NAC, and the 30- and 90-day mortality rates were 2.6% and 5.6%, respectively. We also observed that PC had higher margin positivity compared to RC, but limited data was available on adjuvant therapies. The extent of utilization of NAC and adjuvant therapies could have been variable due to the concern about the tolerability in this age group. Studies have shown that patients with histological tumor-free status or complete pathological response are still prone to develop recurrence or metastasis due to exosomes from the bladder (21,22). Therefore, considering the possible risk of recurrence in patients undergoing PC, a close follow-up is necessary, and combining with adjuvant chemotherapy or chemoradiation as an adjunct may contribute to the oncological and survival benefits.
A study on tetra-modality treatment by Kijima et al. observed that in selected individuals, consolidative PC after transurethral resection of bladder tumor with chemoradiotherapy for MIBC had good oncological and functional outcomes. The 5-year MIBC RFS, CSS, and OS were 97%, 93%, and 91%, respectively (23). Tanaka et al., in a similar study among elderly above 75 years, observed that 5-year RFS and CSS were 98% and 95%, respectively (24). Koga et al., in their research, noted that in selected patients treated with tetra-modality with PC for localized MIBC, all patients reached a 5-year CSS and metastatic RFS endpoint (25). Further randomized studies with strict inclusion and comparing or combining PC with other bladder preservation strategies like concurrent chemoradiation could help us understand their impact on various outcomes.
There are several limitations to be considered in this study, including its database-related retrospective study design. Though the results are from a database-related study, they warrant careful interpretation. It also highlights the necessity of additional evaluation and validation of the role of PC in octogenarians. Propensity matching was done to minimize the effect of confounding factors and selection bias, but it cannot eliminate the bias completely. The tumors located in the dome of the bladder were mostly treated with PC compared to RC, and the pN+ rate was higher in RC compared to PC, suggesting a possible selection bias. Many other factors, like RFS, CSS, chemotherapy dose, and regimen, were unavailable. Details on salvage cystectomy were also not available. As limited data was available on adjuvant chemotherapy and radiation in octogenarians undergoing PC and RC, further studies are required to understand their impact on survival outcomes. Future prospective studies with carefully structured criteria are required to evaluate the role of PLND, treatment failure, and the oncological outcomes of PC in elderly individuals. With bladder preservation protocols gaining popularity, research on PC with a multi-modality approach, transurethral resection with irradiation, and concurrent chemoradiation could help us understand their impact on functional, oncological, and survival outcomes. This also could help in the shared decision-making with healthier elderly individuals concerned about bladder preservation.
Conclusions
Our study on PC and RC among octogenarians with localized MIBC showed that PC is safe and not inferior to RC. Still, the concern about the oncological outcomes and the need for salvage cystectomy limits the use of PC. With bladder preservation protocols gaining popularity, further research focusing on integrating or comparing PC with strategies like concurrent chemoradiation may help us understand the impact of PC on the oncological and survival outcomes among octogenarians.
Acknowledgments
We would like to thank Miami Cancer Institute, Baptist Hospital, for allowing us to conduct the study.
Funding: None.
Footnote
Reporting Checklist: The authors have completed the STROBE reporting checklist. Available at https://tau.amegroups.com/article/view/10.21037/tau-24-139/rc
Peer Review File: Available at https://tau.amegroups.com/article/view/10.21037/tau-24-139/prf
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tau.amegroups.com/article/view/10.21037/tau-24-139/coif). The authors have no conflicts of interest to declare.
Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013).
Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
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