Complications after salvage radical prostatectomy: vesicourethral anastomosis leaks and possible prevention

Next to radical prostatectomy (RP), definitive radiotherapy (RT) represents one of the most common treatment modalities for localized prostate cancer (PCa). Yet, 22%–63% of RT patients will develop biochemical recurrence (BCR) after primary treatment (1,2). While RT is considered a valid second line option after surgical failure, the majority of radiation-recurrent patients will receive androgen deprivation therapy (ADT) (1,2). However, in the setting of local recurrence, standard management with ADT might result in overtreatment without curative intent that causes several life-lasting side effects and harms Quality of life (QoL) (3).