Sperm DNA fragmentation test results reflect the overall quality of the whole semen specimen

Dr. Drevet in his commentary (1) responding to the practice recommendations for Sperm DNA Fragmentation (SDF) testing based on clinical scenarios by Agarwal et al. (2) elegantly discussed the biological effect of DNA fragmentation and its implications to the paternal contribution of the male gamete. The author goes further by elaborating on the likely result of the interactions between sperm with damaged DNA and oocytes with different DNA repair capability.