Use of sperm DNA fragmentation test in ART setting: is it a promising diagnostic test?

Professor Agarwal and colleagues described the different aspects of sperm DNA fragmentation (SDF) testing in clinical setting (1). As they commented, several assays have been introduced for analysis of SDF. However, the SDF testing is not routinely performed in andrology laboratories, despite many studies confirming that high SDF rates in seminal samples is associated with lower pregnancy rates in ART treatment cycles. In order to make an assay become a routine procedure, it should have advantages such as: being inexpensive, simple, less time consuming and highly efficacious.