Recognizing sperm DNA fragmentation testing in clinical evaluation of male fertility

The paper by Agarwal et al. (1) presents guidelines prepared by an expert group indicating the testing of sperm DNA fragmentation (SDF) as a useful diagnostic tool in male fertility evaluation. Evidence based approach is used to indicate that SDF testing would be of immense clinical value and could be used as a reference by practicing urologists and reproductive specialists. The present work reviews the clinically available tests for SDF and the common clinical manifestations encountered in Urology clinics. Convincing evidences have been put forth by the authors advocating clinical utility of SDF in dealing with the cases of male infertility.