Expanding treatment paradigm of high sperm DNA fragmentation

We appreciate the commentary by Drs. Tatem and Brannigan (1) that largely support the practice recommendations proposed by Agarwal et al. (2). We would like to further elaborate on two points in the commentary: (I) the correlation between SDF and varicocele, and (II) treatment for abnormal SDF. We think the discussion may help provide more in depth information to the readers.