Early or delayed radiotherapy after prostatectomy—who really benefits?

The review by Gandaglia et al. (1) clearly shows that we are in the process of drawing a roadmap towards the use of postprostatectomy radiotherapy. The outline is clear: we know that some patients benefit from the combination of surgery and radiotherapy, and we know that these patients have an increased risk of side effects. However, at this moment, the roadmap also shows a lot of gaps; we don’t have clear evidence which patients will really benefit, and there is no clarity about the optimal treatment delivery.