Further evidence supports the clinical utility of sperm DNA fragmentation testing in male infertility workup and assisted reproductive technology

Drs. Johnson and Sandlow critically scrutinized the utility of sperm DNA fragmentation (SDF) testing in clinical scenarios as discussed by Agarwal et al. in their recently published guideline article (1,2). The authors were quite skeptical about the value of SDF testing in male infertility workup and assisted reproductive technology (ART). They ponder that there is insufficient evidence to support obtaining SDF results in specific clinical scenarios presented by Agarwal et al. (2).