Beyond the Gleason score: the prognostic significance of prostate cancer subtypes

We read with great interest the excellent review by Drs. Hassan and Matoso regarding the “Clinical significance of subtypes of Gleason pattern 4 prostate cancer” (1). Our group has published several manuscripts on this important topic that were unfortunately not captured by the author’s search of the current literature. We would therefore like to contribute our experience concerning this emerging subject to update your readership regarding its importance in clinical practice.