Cancer related fatigue in prostate cancer

One of the most commonly experienced toxicities to treatment during cancer management is cancer-related fatigue (CRF) (1). The National Comprehensive Cancer Network defines CRF as “a distressing, persistent, subjective sense of tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and interferes with usual functioning.” (2). This symptom represents a massive detriment to quality of life, as 50–90% of cancer patients will experience this phenomenon during their treatment (3). Furthermore, up to 30% of cancer patients will continue to experience fatigue during follow-up visits after treatment completion (4). Severity of fatigue will vary with the site of malignancy, extent of disease, and treatment modality.