BPH 13. Expression of S100B in the bladder detrusor of patients with benign prostatic hyperplasia combined with type 2 diabetes mellitus

Objective: To understand the expression level of S100B mRNA and protein in the bladder detrusor of patients with benign prostatic hyperplasia (BPH) combined with type 2 diabetes mellitus (T₂DM).

Methods: A total of 20 patients with BPH who were admitted to our hospital from February 2009 to February 2010 were enrolled in this study. Six patients were complicated with T2DM, and the remaining 14 patients showed normal range of blood sugar. All the patients underwent suprapubic prostatectomy, during which a strip tissue of the front wall of bladder sized 1.5 cm × 1.0 cm × 1.0 cm was obtained from each patient. The relative expression of S100B mRNA was determined with real-time quantitative polymerase chain reaction and the relative expression of S100B protein in these tissues was measured with western blot method.

Results: The relatively expression of S100B mRNA in bladder detrusor of patients with BPH and T2DM was 0.399±0.880; in patients with simple BPH, it was 0.102±0.234 (P>0.05). The relative expression of S100B protein in bladder detrusor of patients with BPH and T2DM was 1.21±0.42; in patients with simple BPH, it was 0.92±0.75 (P>0.05).

Conclusions: When urodynamic report of patients with BPH and T2DM shows no obvious weakness of bladder contraction force, the relative expression of S100B mRNA and protein in bladder detrusor is not remarkably different from that in patients with simple BPH. When there is no signs of diabetes cystopathy for patients with BPH and T₂DM, treatment plan can be as same as that for simple BPH. Diabetes education should be strengthened and blood sugar should be controlled actively.