Demographic and temporal trends in transgender identities and gender confirming surgery

Introduction

Transgender and gender non-binary (TGNB) people, individuals whose gender identity or expression differs from their sex assigned at birth, are a diverse population with unique healthcare needs. As visibility of TGNB identities increases, so will the demand for high quality transition-related and general healthcare for TGNB people. Gender Affirming Surgery, also described as gender confirming surgery (GCS), is one domain of TGNB care that requires specialized urologic expertise. In this review article, we discuss trends in demographics and healthcare utilization among the TGNB population.

Demographics of transgender identities

Accurate estimates of the United States TGNB population have been challenging to acquire for multiple reasons, including the broad range of terms used to describe transgender identities, and most notably, lack of data collection in population-based surveys. Federally-administered questionnaires which track the demographics and health of US residents have not historically collected data on gender identity, though some state-level questionnaires have begun to do so (1,2). Utilizing data from the CDC’s Behavioral Risk Factor Surveillance System in 19 states, Flores et al. estimated that 0.56% of US adults (560 per 100,000) identify as transgender. In a systematic review of population-based surveys from 2006–2016 that included gender identity questions, Meerwijk et al. estimated that 0.39% of respondents (390 per 100,000) identified as transgender when this was a categorical option for gender identity. Several smaller studies utilizing limited sources have estimated the U.S, TGNB population as ranging from 38 to 1,647 per 100,000 (3-5). Table 1 summarizes prevalence estimates on transgender identities and gender confirming surgery.

Table 1 Epidemiology of gender confirming surgery. A summary of the literature’s description of the prevalence of TGNB identity, as well as GCS overall and specific procedures in specific populations, is given
Full table

A European systematic review and meta-analysis of “transsexualism” prevalence studies by Arcelus et al. found an overall lower rate of 4.6 per 100,000. However, the review examined literature published from 1968 to 2014, before much of the recent surge in visibility and acceptance around transgender identities. Additionally, most studies based their estimates upon patients referred to and treated at gender clinics (10).

Regardless of specific prevalence rates, most studies demonstrate two clear trends: (I) growth in the proportion of TGNB self-identifying individuals over time; and (II) a higher proportion of TGNB identities among the younger generations. Flores and colleagues note that their 2016 estimate of the percentage of transgender-identifying adults in the U.S. is double their 2011 estimate, which they attribute to improvement in survey methods (11). Arcelus et al. also describe a general increase in TGNB individuals in Europe within their study period. Greater visibility and acceptance of TGNB individuals, and as a result, greater willingness to self-identify as TGNB and seek transition, may contribute to these trends.

TGNB identification appears to be more common among younger age groups. By the Williams Institute’s estimates, TGNB prevalence among adults is highest in the 18–24 years old age group at 700 per 100,000 (0.7%), compared with 600 per 100,000 (0.6%) in those aged 25–64 and 500 per 100,000 (0.5%) in those aged 65 and older. Similarly, 42% of respondents to the 2015 U.S. Transgender Survey (USTS) were between the ages of 18–24, although the surveyed sample is likely skewed based on online survey distribution. The USTS was distributed by the National Center for Transgender Equality and is the largest and most impactful survey to date assessing the needs of the TGNB community, including 27,715 respondents from across the U.S. A recent study of high-school students in Minnesota reported exceptionally high rates of TGNB identities, as high as 2,700 per 100,000 (6). This voluntary survey was administered to 9th and 11th graders in 2016 by the Minnesota Department of Education. Although the Minnesota study is an outlier in its high prevalence rates, it is among the most recent and targets a younger demographic than other prevalence studies, and thus may be indicative of future trends in TGNB identity prevalence.

Evidence supports that TGNB people begin to identify as TGNB when they are at a relatively young age. According to USTS results, by age 20, 94% of respondents began to feel that their gender was different from the sex assigned at birth, 73% of respondents began to think they were transgender, and 52% began to tell others that they were transgender (12). These findings were consistent across respondent age groups, which may suggest that reports of growing TGNB prevalence could be attributed to increased awareness, acceptance and self-reporting of TGNB identities among younger generations than an actual increase in prevalence.

Regarding relative prevalence of specific identities, two main trends are described widely in the literature. First, transgender females (females assigned ‘male’ at birth) are usually identified at higher rates than transgender males (males assigned ‘female’ at birth). In some studies, the proportion of transgender women to men is as high as 2:1 (6,10). However, these ratios should not be taken as a definitive indication of actual population sizes, given the limitations in methodology used to record them. Many studies survey subjects enrolled in plastic surgery, endocrinology, or primary care clinics, and as such only reflect populations that are well-integrated into existing healthcare systems and accessing care. Furthermore, some estimates derived from global data, and definitions of transgender and non-binary identities vary substantially across cultures (10).

Another notable demographic trend is the high prevalence of non-binary identities. “Non-binary” is generally used as an umbrella term encompassing gender identities that are not exclusively masculine or feminine, or that lie outside the traditional gender binary. In the 2015 USTS, up to 35% of respondents identified as non-binary or genderqueer, an equal number to transgender women and men (6,7). The survey of Minnesota high-schoolers found that about half of TGNB respondents identified primarily as non-binary (6).

Studies evaluating racial and ethnic demographic trends suggest that non-white groups are overrepresented in TGNB populations. Flores et al. estimate transgender prevalence among non-Hispanic whites at approximately 480 per 100,000, lower than the 770 per 100,000 for non-Hispanic blacks, 840 per 100,000 for “Hispanic/Latino” and 640 per 100,000 for “other non-Hispanic” categories (13).

The diverse, evolving language used to describe gender identities can also lend to difficulty with accurate identification of TGNB individuals, particularly for non-binary individuals. In future efforts to characterize TGNB populations, appropriate identification may be achieved by a two-step approach: by asking individuals their current gender, followed by their sex assigned at birth (14,15). This method avoids pathologizing TGNB status, and in the healthcare setting may facilitate conversations between patients and providers regarding gender identity. Electronic medical record systems have begun to include gender identity questions within their data intake fields, adhering to U.S. Centers for Medicare & Medicaid Services mandates (16,17).

Epidemiology of transgender health and medical treatment

Significant health disparities exist for the transgender population and stem from a number of sources: insufficient provider training in healthcare needs specific to TGNB individuals; direct interpersonal or systemic discrimination perpetuated by healthcare providers and institutions; and broader sociopolitical discrimination leading to challenges in finding stable employment and housing, among other chronic stressors (17,18). TGNB identities are associated with increased risk of sexually transmitted infections such as HIV and psychiatric comorbidities such as depression and anxiety when compared to the general population (7).

Gender affirming healthcare is effective and medically necessary for those TGNB individuals who seek it (19). Psychological, hormonal and surgical care for appropriately selected individuals has been unambiguously associated with improvements in gender dysphoria and decreased rates of psychiatric comorbidities (20). A growing number of professional societies have published position statements supporting public and private insurance coverage of gender affirming care (21-25). Provision of such care has historically been compromised by categorical exclusion of transgender-related healthcare by insurers (26). Up to 25% of transgender individuals who sought hormone therapy coverage were denied by their insurers (7). The Affordable Care Act, however, created a shift away from health insurance that excludes based on preexisting conditions to a coverage specifically for transgender care (27).

Healthcare systems are currently ill-equipped to meet the demand of a growing transgender population. The literature demonstrates numerous instances of transgender individuals being denied medical care related to their gender identity (28). According to 2015 USTS results, 23% of respondents did not see a doctor when they needed to because of fear of being mistreated as a transgender person (7). Ninety-one percent of TGNB people reported wanting counseling, hormones, and/or puberty blockers, however only 65% reported ever having any of these (7). Inadequate medical treatment of transgender-related health issues and psychiatric disorders has dire consequences. Serious psychological distress and suicide attempts have been reported at approximately 40%, almost nine times the national suicide rate in the general US population (4.6%) (29). Seven percent of respondents had attempted suicide in the past year alone (7).

Outside of commonly-discussed transgender health sequelae such as HIV, substance abuse, and psychiatric disorders, relatively little is known about transgender-specific preventive care needs. For example, ideal regimens for breast, cervical, and prostate cancer screening in TGNB individuals are poorly understood. Longitudinal studies are needed to assess mental and physical health conditions prevalent in the TGNB population.

Growing utilization of gender confirming surgery

In the most robust survey to date, 25% of TGNB respondents report having undergone some form of GCS. Other smaller studies report slightly higher ranges (up to 35%), though these are typically carried out in healthcare settings, selecting for those who are accessing care (7,8).

Existing estimates potentially underestimate GCS utilization, due to many of the same factors that limit transgender prevalence studies. GCS procedures are likely under-captured based on ICD-9 or 10 and CPT (Current Procedural Terminology) codes alone, which may not accurately reflect the range of affirming procedures TGBN individuals seek. Many transgender people do not have transgender-related ICD codes or are enrolled as a gender identity other than that with which they identify. In one survey of 122 transgender men, 35% were enrolled with their insurance providers as female patients (30). Furthermore, many prevalence studies were carried out in previous years, or use aggregate patient populations over several years. These studies report data from periods when GCS was either less common or less frequently recorded. Finally, the wide range of research methods currently employed (online surveys, surgery clinic surveys, claims-based dataset analysis, single institution-reported case volumes) complicate any year-to-year comparison of prevalence.

What is certain, however, is that GCS is a rapidly-expanding field. Of all procedures recorded by the American Society for Plastic Surgeons (ASPS), GCS was among the most rapidly increasing between 2016 to 2017 (31). GCS increased by 155% in this period, with a 289% increase for transgender men and a 41% increase for transgender women. These rates are significantly increased from the more modest but still marked net 19% increase in GCS from 2015 to 2016 reported by ASPS.

A number of factors have been identified to influence GCS utilization among transgender people, namely age, income, and race. Older age is associated with increased utilization. One study found a 4% increased likelihood of having had GCS for each additional year of age (9). Another found a positive association with age over 50 years (32). Affluence was also associated with receipt of GCS. The main effect appears to be proportionally decreased GCS usage with annual income below $35,000–50,000 (32). There appears to be a relatively smaller effect of increased income over $50,000. While only 12% of transgender people without income and 15% of people with income less than $10,000 per year report having had GCS, 43% of people with income over $50,000 report having had some type of GCS. Black and Latina races appear to be negatively correlated with GCS utilization, although the effect is small and requires further exploration (33).

A number of barriers limit patient access to GCS. Among the most important of these are financial concerns. By one survey, about 25% of transgender individuals report that the largest barriers to accessing GCS was cost (9). Transgender populations are affected by poverty, unemployment, and lack of insurance at higher rates than the general population (7). Historically, many have been forced to pay out of pocket for GCS, due to categorical exclusions of GCS (26). Still, even after Section 1557 of the Affordable Care Act forbade discrimination on the basis of sex or gender identity, many insured transgender individuals find themselves without coverage for GCS (27,34). As recently as 2015, 25% of transgender individuals reported having difficulty with their insurance providers related to their transgender identity, and over half were denied coverage for GCS (7).

However, insurance coverage of GCS may indeed increase in coming years, due to societal or legal pressures. Financially, expanding coverage of GCS is feasible and beneficial for public health (35). The public health benefits extend beyond just treating gender dysphoria in a small minority of people, but are largely derived from generally decreased rates of several other costly endpoints like HIV, depression, and suicide.

Trends in specific gender confirming procedures

In general, GCS is more common in transgender men than in transgender women, and least common in gender non-binary or nonconforming populations. Transgender men self-report GCS prevalence at rates of 42–54%, while transgender women report it at around 28%, and non-binary individuals at around 9% (7,8). By one study, a transgender male identity was associated with an odds ratio for having had GCS of 1.87, compared with being transgender female (9).

Across transgender populations, chest (“top”) surgery is more common than genitourinary reconstructive (“bottom”) surgery. Chest surgery is generally reported at about twice the rate of genital GCS. In studies that assessed transgender men and women as an aggregate, chest surgery has been reported at rates between 8–25%, and genital surgery at 4–13% (8,9). This could be due to a number of factors. Chest surgery may be more important to outward gender expression for many individuals, as the presence or absence of breast tissue is more readily visible in daily life than are the genitalia. Chest surgery is likely more accessible as well, as most plastic surgeons are familiar with breast augmentation and mastectomy for non-gender affirming implications, while relatively few are trained in techniques required for transgender genital reconstruction (36).

Genital GCS is generally less common than chest surgery, with prevalence rates of about 25–50% for transgender men and 5–10% for transgender women (7,9,32). For transgender women, genital GCS comprises a number of procedures, including vaginoplasty (most commonly intestinal or penile inversion) with labiaplasty and/or clitoroplasty, penectomy, and orchiectomy. Transgender women report bottom surgery at rates between 5–13% (7-9,32). Even more transgender women desire bottom surgery in the future: between 45–54% (7,9). Among non-binary people assigned male at birth, 1% have had vaginoplasty or labiaplasty, and 11% desire these in the future (7).

Masculinizing genital GCS aims to remove ‘female’ genitalia (i.e., vagina and labia) and/or create a neophallus. Extirpative procedures such as hysterectomy and salpingo-oophorectomy appear to be more common than those to reconstruct genital anatomy, which include phalloplasty and metoidioplasty with or without urethral lengthening, scrotoplasty, colpectomy, and penile and testicular implant placement. By USTS 2015 results, hysterectomy is significantly more common than any type of neophallus-creating procedure: 14% of transgender men have had a hysterectomy, while another 57% want one in the future (7). Hysterectomy is also relatively common in non-binary people assigned female at birth: 2% have had it and another 30% want it in the future.

Phalloplasty and metoidioplasty are the two primary genital reconstructive procedures for transgender male individuals, each with their own urinary, sexual, and aesthetic considerations (37,38). Phalloplasty affords a larger phallus that may allow for standing micturition and penetrative sexual intercourse after urethral lengthening and penile implant placement; however, it is costly, usually requires multiple procedures, has high complication rates, and may result in a stigmatizing donor site scar. Metoidioplasty, or mobilization of the hormonally augmented clitoris with or without urethral lengthening, typically results in a smaller phallus, but can be performed in a single operation with preservation of native tissue sensation. As a whole, less than 5% of transgender men have had procedures to create a phallus (8,32). One survey distinguished between the surgical options, reporting that 3% of transgender men have had phalloplasty and 19% want it in the future, while 2% have had metoidioplasty and 25% want it in the future (7).

Transgender women and non-binary individuals assigned male at birth may commonly seek procedures that feminize other highly-gendered aspects of their outward presentation, such as the face, tracheal cartilage, body contour, body hair, and voice. Such procedures constitute 10.6% of all transgender inpatient hospital visits (7,8,32,39,40). Prevalence rates are about 50% for hair removal, 3–8% for facial feminization, and 1% for feminizing phonosurgery. Prevalence for silicone injections, a risky procedure not endorsed or performed by medical professionals, is around 16.7%, and may have serious or fatal health consequences (41,42). These ancillary procedures are much less common in transgender men (7).

Limitations

A number of factors specific to TGNB individuals limit estimates of prevalence and healthcare utilization. Transgender demographics are difficult to study, as identifying individuals as transgender can publicly ‘out’ them, potentially putting them in physical danger or subjecting them to outward discrimination. Therefore, many of the largest studies on transgender epidemiology are anonymous online surveys, which preclude any verification of patients’ identities, and preferentially sample those respondents with computers and internet access. Furthermore, many electronic medical records do not record gender identity or sexual orientation data. This makes is difficult to distinguish between GCS and non-gender-related indications. For example, such systems could not distinguish between a prophylactic breast cancer mastectomy in a cisgender woman and a gender-affirming top surgery in a transgender man. Lastly, relatively little data, epidemiologic or otherwise, is available on the health needs and practices of non-binary people, which may be quite distinct from those of transgender men and women.

Conclusions

As visibility of transgender identities have increased in recent years, so too has the prevalence of GCS. Gender affirming care is highly effective for treating gender dysphoria in transgender individuals who seek it, but a number of sociopolitical and economic factors have limited access to care. Further developments in patient-reported outcomes research, transgender-specific provider education, and technical advancements to GCS procedures will all be necessary to meet the healthcare needs of a growing TGNB population (18,43).

Acknowledgments

None.

Footnote

Conflicts of Interest: The authors have no conflicts of interest to declare.

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