CU 61. Sigmoidcystoplasty to treat bladder contraction of abusing Ketamine

Background: Little is known about young ketamine abusers presented with lower urinary tract symptoms.

Objective: To discuss the method of treatment of bladder contracture caused by abusing Ketamine. Design, Setting and Participants: Between November 2006 and February 2009, 25 patients with lower urinary tract symptoms (LUTS) for abusing ketamine were treated with augmentation cystoplasty in our hospital, and patient data were collected retrospectively.

Intervention: We obtained a detailed history and physical examination along with cystoscopy, urine culture, urinalysis, and urine cytology in all patients. All patients underwent bladder biopsy, which were all reviewed by a single pathologist. IVP and other ancillary tests were obtained as indicated. All patients were required to withdraw the narcotics and the experimental medine were given, all symptoms without obvious alleviated, we use Sigmoidcystoplasty to treat them.

Measurements: We use Sigmoidcystoplasty to treat them, urination easy and smooth.

Results and Limitations: Sigmoidcystoplasty is effective, follow up from 6 months to 24 months, Urodynamics significant improvement. A marked increase in the Q_max, residual urine significantly reduced. No complainted urinary incontinence, no enuresis, frequency, urgency. Urine routine is no abnormality seen. Cystography could not find ureter reflux, bladder capacity is larger than before. B ultrasound examinetion of 23 cases demonstrated the disappearance of bilateral hydronephrosis or significant improvement.

Conclusions: Sigmoidcystoplasty could enlarge bladder capacity and compliance, ameliorate bilateral hydronephrosis and the lower urinary system dysfunction, and improve the patients quality of life.