MR 15. Sperm donation and Sperm banking for male reproduction salvage in China: Multicenter retrospective study

Objective: To explore the current condition of sperm donation and its clinic use and sperm banking for the purpose of fertility salvage in China.

Methods: The retrospective study was based on the data collected from January 2003 to December 2010 in four human sperm banks. The investigation included two parts: (I) the investigated items concerning donors included: the intention about sperm donation; the factors of drop-out; the reasons of midway withdraw of qualified donors; parameters of cryostored samples pre- and post-frosing, assistant reproductive techniques (ART) cycle number, pregnant rate and birth rate; (II) the data collected from 85 males who had their semen cryopreserved in sperm banks above. The investigation included urogenital history, indication for cryopreservation, semen parameters and use of semen or not.

Results: From January 2003 to December 2010, a total of 19,471 sperm donors were screened and 6467 donors (33.2%) were recruited. The main reasons for non-recruitment were unqualified semen parameters (55.0%) and positive results for sexually transmitted disease (7.9%). There were 327 (1.7%) qualified donors who withdrew from the program because of frustration by unqualified semen parameters later on, participation merely for free medical tests, or job transfer. During the past 8 years, 488,389 vials of donors' semen were cryopreserved. In 36,438 artificial insemination with donor sperm (AID) cycles, the clinical pregnancy rate was 23.9%, and the live-birth rate was 16.6%. In 7,148 in vitro fertilization (IVF) cycles, the clinical pregnancy rate was 45.8%, and the live-birth rate was 35.2%. There were 1,584 males who banked their semen during the past 8 years in the clinics above. About 1.9 % (30/1548) of the cryopreserved semen samples were from cancer patients, among them, about 88.9% (1374/1548) banked semen for ART purpose, and 8.6% (134/1548) had male infertility diseases (such as anejaculation, severe oligozoospermia and obstructive azoospermia). The total use rate of cryopreserved semen was 22.67 % (352/1548), with live births of 119, among these, the cancer group use rate was 6.7% (2/30), with 1 live birth by ICSI; the ART group use rate was 23.2% (319/1374), with 106 live births; reproductive diseases group use rate was 23.1% (31/134), with 12 live births.

Conclusions: The human semen banking in the China had developed into a regulary stage after the implementation of ‘Rules and Guidelines'. The quality of donor sperm cryopreserved had increased. All the measures play an important role in the goal that everyone enjoys reproductive health for all of the people in our country. Sperm banking can also preserve male reproductive potential, but the semen cryopreservation in Shanghai area is too low. It should be recommended.