PC 08. The relationship of prostate volume, prostate biopsy cores and prostate cancer (Pca) detection rate

Objective: To investigate the relationship of prostate volume, prostate biopsy cores and Pca detection rate.

Methods: A total of 292 patients with PSA from 4 to 20 ng/mL, with or without abnormal DRE, underwent 12-core prostate biopsy from January 2007 to December 2009. Transrectal ultrasound was used to determine prostate volume. 12-core biopsy protocol originated from classic 6-core protocol. We divided all patients into <30 mL, 30-60 mL, 60-90 mL, >90 mL groups according prostate volume. And then we compared the Pca detection rates of 6-, 8-, 10- and 12-core protocols in each groups.

Results: The total Pca detection rate was 25.0% (73/292). In <30 mL group, Pca detection rates were same between each protocols (39.13%, 21/54). In 30-60 mL group, Pca detection rates of 6-core (21.3%, 23/108), 8-core (23.1%, 25/108), 10- core (23.1%, 25/108) and 12-core (24.1%, 26/108) protocols were not significantly different (P>0.05). In 60-90 mL group, 6-core (12.9%, 12/93) protocol had significantly lower Pca detection rate (P<0.05) than 8-core (19.4%, 18/93), 10-core (20.4%, 19/93), 12-core (20.4%, 19/93) protocols. In >90 mL groups, Pca detection rates of 6-core (8.1%, 3/37), 8-core (8.1%, 3/37) protocols were significantly lower (P<0.05) than 10-core (18.9%, 7/37), 12-core (18.9%, 7/37) protocols.

Conclusions: Prostate volume could be an important factor for how many cores which we choice for prostate biopsy. Increasing cores would not improve Pca detection rate without considering prostate volume.