O 01. Prognostic factors in Chinese patients with penile invasive squamous cell carcinoma: Chronological age and lymph node metastasis were two independent factors

Introduction: Several factors had been evaluated in the prognosis of penile cancers. However, there was still few data on Chinese patients.

Methods: We performed a retrospective study to assess the treatment outcome and prognostic factors in Chinese patients with penile invasive squamous cell carcinoma. We reviewed the medical records of 93 consecutive patients with penile cancers who were treated at our institution from January 2002 to December 2010. Eighty-three patients were invasive Squamous cell carcinoma. The Kaplan-Meier method and log-rank test and multivariate Cox proportional hazard models were used to identify the prognostic factors predicting for survival. Univariate and multivariate logistical regression analysis were used to analyze the predictive factors for lymph node metastasis.

Results: A total of 55 patients were followed (median duration 27 months (range 2 to 89.0). Mean patient age was 53.3 years (range 29 to 82). Twelve patients (20%) died during follow up. One died of pulmonary carcinoma, and other 11 patients died from metastatic disease. In univariate analysis, the following factors were significantly associated with poor prognosis: older age (>50y, P=0.045), radical resection (compared with partial resection, P=0.043), high histological grade (P=0.015) and lymph node metastasis (P<0.001). Using multivariate Cox proportional hazard models, chronological age (P=0.016) and lymph node metastasis (P=0.003) were significant independent predictors of outcome. The histological grade was associated with lymph node metastasis (P=0.0022) in multivariate logistical regression analysis.

Conclusions: In our series, chronological age and lymph node metastasis were independent predictors of survival from penile invasive squamous cell carcinoma. The histological grade was an influential predictive factor of lymph node metastasis of penile cancer.