O 02. PLGA biodegradable Scaffold cografting with autologous ADSC on penis girth enhancement

Objective: To evaluate the efficacy and safety of tissue engineering surgery with PLGA Biodegradable Scaffold (Maxpol-T) cografting with adipose derived stem cells(ADSC) on penis girth enhancement.

Methods: Forty-five adult New Zealand male rabbits were divided into three groups, including the shame operation group (group A), grafted Maxpol-T only (group B)and Maxpol-T cografted with ADSC (group C), ADSC were isolated from the skin of scrotum of rabbits and seeded into PLGA Scaffold, then transplanted under the deep fascia of penis. The efficacy and safety of girth enhancement were continuously observed for 6 months.

Results: The flow cytometry of ADSC showed CD105(+), CD31(-), CD34(-), CD45(-), CD106(-). 6 months later, no obvious rejection and inflammation were observed. The penis girth of group C was augmented significantly compared with that in group A and group B (P<0.001). There was no significant difference between the penis girth of group A and group B (P>0.05). Region histopathological analysis showed that subcutaneous tissue thickening and desmoplasia accompany with new vessels were observed in group B and group C.

Conclusions: Tissue engineering surger y with PLGA Biodegradable Scaffold cografting with ADSC on penis girth enhancement is safe and effective.