Abstract publication Basic research
AB197. The prevalence of FSH autoantibodies in the aging male
Bing Yao, Xiaojian Yang, Weidong Cao, Guohong Wang, Huiru Xu, Chenyang Wang, Lin Hou, Yufeng Huang, Xiaojun Li, Yingxia Cui
Institute of Clinical Laboratory Medicine, Nanjing Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing 210002, China; Department of Urology, Institute of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710000, China
*These authors contributed equally to this work.
Aim: This study was conducted to evaluate the prevalence of FSH autoantibodies in aging male and further observe the correlation between FSH autoantibodies and reproductive hormones.
Methods: The serum samples were collected from 192 normal men whose mean age was 49.47±18.51 (range, 18-88) years and the level of sera FSH, LH, T, SHBG and FSH antibody was detected by RIA and ELISA assay, respectively. Free testosterone index (FTI) was analyzed based on the serum level of total T and SHBG.
Results: The positive incidence of anti-sera against FSH in the group, aged 60-89 years, was significantly higher than that in the group, aged 18-59 years (20.00%, 14/70 vs. 9.84%, 12/122) (P
Conclusions: Aged men were associated with higher incidence of FSH autoantibodies. The level of serum FSH in aged man could be affected by FSH autoantibodies. Anti-sera against FSH in men might be involved in a certain physiologic process of male aging.
Keywords: FSH autoantibodies; FSH; male aging
doi: 10.3978/j.issn.2223-4683.2014.s197
Cite this article as: ao B, Yang X, Cao W, Wang G, Xu H, Wang C, Hou L, Huang Y, Li X, Cui Y. The prevalence of FSH autoantibodies in the aging male. Transl Androl Urol 2014;3(S1):AB197. doi: 10.3978/j.issn.2223-4683.2014.s197
