AB116. Role of the novel herbal formulation (WSY-1075) in a refractory detrusor overactivity due to bladder outlet obstruction

Objective: To evaluate whether a new herbal formula (WSY-1075) could prevent partial bladder outlet obstruction induced overactive bladder and to investigate its anti-oxidant and anti-inflammatory effects.

Methods: Twenty four male Sprague-Dawley rats were used in the study. The experimental group was partially obstructed via perineal ligation. After 2 weeks, the rats were randomly divided into one of three treatment groups: control (n=8), oxybutynin (3 mg/kg) (n=8), and WSY-1075 (400 mg/kg) (n=8). After 4 weeks of treatment, ligations were removed and cystometrograms were performed twice a week apart. The pro-inflammatory cytokine levels, anti-oxidant effects and histological findings were also noted.

Results: The use of oxybutynin and WSY-1075 showed significantly increased bladder compliance and diminished non-voiding contractions. Treatment with Oxybutynin and WSY-1075 significantly decreased pro-inflammatory cytokine levels. The levels of superoxide dismutase increased in the WSY-1075 group, which confirmed the anti-oxidant effect of WSY-1075.

Conclusions: WSY-1075 may be effective in treating detrusor overactivity do not respond to resolution of bladder outlet obstruction.

Keywords: Bladder outlet obstruction; herbal formulation