Utilizing intraoperative frozen section examination (IFSE) for diagnosis and treatment in a high-clinical-suspicion prostate cancer (PCa) cohort based on ¹⁸F-PSMA PET/CT and MRI: a pilot study

The diagnosis of prostate cancer (PCa) relies predominantly on definitive histopathological assessment. Although intraoperative frozen section examination (IFSE) is infrequently employed in prostate biopsy procedures, its integration with radical resection has been more widely adopted in other solid tumor settings. This study aims to evaluate the feasibility of an integrated diagnostic and therapeutic strategy—guided by IFSE—for patients with clinically high-risk or radiologically suspicious PCa.