Letter to the Editor


The role of adipose stroma in prostate cancer aggressiveness

Mikhail G. Kolonin, John DiGiovanni

Abstract

Resistance of prostate cancer to treatment remains a challenge. Surgery, chemotherapy, and androgen deprivation therapy cure most patients with early-stage disease. However, metabolic reprogramming, androgen receptor bypass, and sustained immunotolerance results in treatment-refractory prostate cancer that progresses to metastatic and lethal stages.

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