Holding a MIRror up to the robustness of the prostate cancer urinary transcriptome

There is great interest in the field of liquid biopsies across the field of oncology. They hold exciting promise as a tool to study circulating tumour cells, nucleic acids and extracellular vesicles, which may aid cancer screening/early detection, monitoring response to therapies and detecting minimal residual disease. Urine is a particularly attractive non-invasive liquid biopsy for urological malignancies, due to its ease of (serial) collection and direct proximity to primary tumour cells of the prostate, bladder and kidney.